目前，真菌感染随着广谱抗生素的滥用和介入性治疗的广泛应用呈现逐年上升的趋势。其中，白念珠菌是人体内一种最常见的机会型致病真菌，60-70%侵入性真菌感染是由白念珠菌引起的。本实验室将以探究白念珠菌致病机制为基础来建立致病真菌与宿主互作关系的实验平台（整合遗传学、生物化学、系统生物学和实验动物感染模型），以期找到新的药物靶点来有效对抗真菌的系统性感染。 主要研究工作包括：1）真菌对宿主体内环境因子的感受器的鉴定和分子机制研究；2）病原真菌从共生菌到致病菌的转换机理；3)真菌的效应因子调控宿主免疫系统的机制；4）真菌耐药机制的研究以及抗真菌药物的筛选。
Qiangqiang Sun, Bin Dong, Dandan Yang, Jing Yu, Tianhao Ren, Tianxu Wang, Lianjuan Yang, Yang Lu*, Chang Su*. (2023) Zcf24, a zinc‐finger transcription factor, is required for lactate catabolism and inhibits commensalism in Candida albicans. Molecular Microbiology 119(1): 112-125.
Xun Sun, Jing Yu, Cheng Zhu, Xinreng Mo, Qiangqiang Sun, Dandan Yang, Chang Su*, Yang Lu*. (2023) Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans. eLife 12(e84155).
Mao Zhang, Cheng Zhu, Yuanyuan Duan, Tongbao Liu, Haoping Liu, Chang Su* and Yang Lu*. (2022) The intrinsically disordered region from PP2C phosphatases functions as a conserved CO2 sensor. Nature Cell Biology 24 (7) 1029-1037
Highlighted at Nature Reviews Molecular Cell Biology, CO2 sensing through PP2C condensates. 23 (4) 519 Highlighted at Nature Cell Biology, Intrinsically disordered CO2 sensors. 24 (7) 1013-1014 Highlighted at Nature Chemical Biology, Sensing the air. 18 (8) 793 Recommended by Faculty Option.
Kang Xiong#, Chang Su#, Qiangqiang Sun and Yang Lu*. (2021) Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans. Antimicrobial Agents and Chemotherapy 65 (2) e01584-20
Qiangqiang Sun, Kang Xiong, Yuncong Yuan, Jing Yu, Lianjuan Yang, Chao Shen, Chang Su*, and Yang Lu*. (2020) Inhibiting fungal echinocandin resistance by small-molecular disruption of geranylgeranyltransferase type I activity. Antimicrobial Agents and Chemotherapy 64 (2) 02406-19
Yang Lu*#; Chang Su#; Shatarupa Ray; Yuncong Yuan; Haoping Liu*. (2019) CO2 signaling through the Ptc2-Ssn3 axis governs sustained hyphal development of Candida albicans by reducing Ume6 phosphorylation and degradation. mBio 10 (1) 02320-18
Chang Su#; Jing Yu#; Qiangqiang Sun; Qian Liu; Yang Lu*. (2018) Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition. Molecular Microbiology 108(4): 410-423
Chang Su#; Yang Lu#; Haoping Liu. (2016) N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi. Nature Communications 7:12916
Yang Lu, Chang Su, and Haoping Liu. (2014) Candida albicans hyphal initiation and elongation. Trends in Microbiology 22(12): 707-14.
Yang Lu#, Chang Su#, Ohimai Unoje, and Haoping Liu*. (2014) Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. Proc Natl Acad Sci 111(5): 1975-80.Recommended by Faculty 1000.
Yang Lu, Chang Su, Norma V. Solis, Scott G. Filler, and Haoping Liu*. (2013) Synergistic regulation of hyphal elongation by hypoxia, CO2, and nutrient conditions controls the virulence of Candida albicans. Cell Host & Microbe14(5): 499-509.Recommended by Faculty 1000.
Yang Lu, Chang Su, and Haoping Liu*. (2012) A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans. PLOS Pathogens8(4): e1002663.
Yang Lu, Chang Su, Allen Wang, and Haoping Liu*. (2011) Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance. PLOS Biology 9 (7): e1001105.Recommended by Faculty 1000.
Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu*, and Jiangye Chen*. (2008) Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans. Molecular Biology of the Cell 19 (10): 4260-72.
