学习经历

2003－2009 中科院上海生命科学研究院生物化学与细胞生物学研究所，博士

1999－2003 南开大学生命科学学院，学士

主要工作经历与任职情况

2016－至今 武汉大学生命科学学院，副研究员

2015－2016 加州大学欧文分校医学院，研究助理

2010－2015 加州大学欧文分校医学院，博士后

研究内容

白念珠菌是人体内一种最常见的机会性致病真菌，以共生菌的状态生活在人体的口腔、皮肤、肠道和女性阴道中，但在免疫有缺陷的人群当中会引起浅层感染和致人死亡的系统性感染。近年来，由于各种广谱抗生素的滥用，器官移植和介入性治疗的广泛应用，糖尿病、艾滋病以及癌症病人持续增加，导致白念珠菌系统性感染逐年上升。

结合多种实验方法和手段，本实验室将从以下几个方面开展研究工作:

1）白念珠菌在宿主体内的营养代谢调控其形态发生和致病性的分子机制；

2）病原真菌的社会性参与调控毒力、抗药性以及发育分化的机理；

3）白念珠菌如何通过与肠道菌群的相互作用促进其在体内的生长繁殖以及毒力发挥。

通过对病原真菌致病机理的研究，以期找到新的药物靶点来有效对抗真菌的系统性感染。

主持课题项目

国家自然科学基金面上项目

国家自然科学基金青年项目

湖北省自然科学基金面上项目

湖北省自然科学基金青年项目

武汉大学自主科研项目

发表的论文（^#并列第一作者，*通讯作者）

1. Qiangqiang Sun, Bin Dong, Dandan Yang, Jing Yu, Tianhao Ren, Tianxu Wang, Lianjuan Yang, Yang Lu*, Chang Su*. (2023) Zcf24, a zinc‐finger transcription factor, is required for lactate catabolism and inhibits commensalism in Candida albicans. Molecular Microbiology 119(1): 112-125.

2. Xun Sun, Jing Yu, Cheng Zhu, Xinreng Mo, Qiangqiang Sun, Dandan Yang, Chang Su*, Yang Lu*. (2023) Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans. eLife 12(e84155).

3. Mao Zhang, Cheng Zhu, Yuanyuan Duan, Tongbao Liu, Haoping Liu, Chang Su* and Yang Lu*. (2022) The intrinsically disordered region from PP2C phosphatases functions as a conserved CO₂ sensor. Nature Cell Biology 24(7): 1029-1037. Highlighted at Nature Reviews Molecular Cell Biology, CO₂ sensing through PP2C condensates. 23(4): 519; Highlighted at Nature Cell Biology, Intrinsically disordered CO2 sensors. 24(7): 1013-1014; Highlighted at Nature Chemical Biology, Sensing the air. 18(8): 793; Recommended by Faculty Option.

4. Kang Xiong#, Chang Su#, Qiangqiang Sun and Yang Lu*. (2021) Efg1 and Cas5 orchestrate cell wall damage response to Caspofungin in Candida albicans. Antimicrobial Agents and Chemotherapy 65(2): e01584-20.

5. Qiangqiang Sun, Kang Xiong, Yuncong Yuan, Jing Yu, Lianjuan Yang, Chao Shen, Chang Su* and Yang Lu*. (2020) Inhibiting fungal Echinocandin resistance by small-molecule disruption of Geranylgeranyltransferase type I activity. Antimicrobial Agents and Chemotherapy 64(2): e02046-19

6. Yang Lu*#, Chang Su#, Shatarupa Ray, Yuncong Yuan, and Haoping Liu*. (2019) CO2 signaling through the Ptc2-Ssn3 axis governs sustained hyphal development of Candida albicans by reducing Ume6 phosphorylation and degradation. mBio 10(1): e02320-18.

7. Chang Su^#, Jing Yu^#, Qiangqiang Sun, Qian Liu, and Yang Lu*. (2018) Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition. Molecular Microbiology 108(4): 410-423.

8. Chang Su, Jing Yu, Yang Lu^*. (2018) Hyphal development in Candida albicans from different cell states. Current Genetics 64(6):1239-1243.

9. Chang Su^#, Yang Lu^#, and Haoping Liu. (2016) N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi. Nature Communications 7:12916.

10. Yang Lu^#, Chang Su^#, Ohimai Unoje, and Haoping Liu*. (2014) Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. PNAS 111(5): 1975-80. Recommended by Faculty 1000.

11. Chang Su^#, Yang Lu^#, and Haoping Liu. (2013) Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity. Molecular Biology of the Cell 24(3): 385-97.