学习经历

2002.09～2008.12 武汉大学生命科学学院，微生物系，博士

1997.09～2001.06 武汉大学生命科学学院，生物学基地班，学士

主要工作经历与任职情况

2020.07 - 至今     武汉大学生命科学学院，副教授

2011.11 - 2013.11 美国中佛罗里达大学医学院，博士后

2009.07 - 2020.07 武汉大学生命科学学院，讲师

2001.09 - 2002.07 共青团中央青年志愿者研究生支教团，支教

主要社会兼职

中国典型培养物保藏中心副主任

国际细胞系鉴定委员会（ICLAC）委员

主要科研奖励和个人荣誉

1. 药品/生物制品生产用细胞质量控制关键技术研究与应用，湖北省科技进步二等奖，湖北省科技厅，2016，排名二

2. 21位点STR数据库的建立及应用，第二届全国大学生生命科学创新创业大赛，指导教师二等奖（创新），2017年

3. 2019年度武汉大学生命科学学院优秀教学奖

4. 2021-2022学年武汉大学优秀教学业绩奖（实验实践课程类）

研究内容

细胞生物学：细胞系、原代细胞、干细胞及类器官的培养体系建立、质量控制及应用。

病毒感染细胞生物学：口蹄疫病毒持续感染机理的研究，病毒与宿主相互作用研究。

主持课题项目

1. 国家实验细胞资源共享平台建设，科技部，子课题主持人，个人经费270万。

2. 国家生物医学实验细胞资源库建设，科技部，子课题主持人，个人经费210万。

3. STING在肿瘤组织中的表达与调控机制，中央高校基本科研业务费，主持，20万。

4. 宫颈癌类器官药物筛选模型的建立，湖北省自然科学基金面上项目，主持，8万。

5. 病毒分离纯化虚拟仿真实验项目的建设，武汉大学，主持，16万。

6. 细胞系质量控制服务，横向，主持，330万。

7. 细胞系质量控制新技术开发，横向，主持，210万。

8. 呼吸道病原体多重微流核酸检测试剂及全自动微流控PCR一体机性能验证评估，横向项目，主持，49万。

发表的论文（^#并列第一作者，^*通讯作者）

1. Pu Yang#, Yuncong Yuan#, Yidan Sun, Bonan Lv, Hang Du, Zhou Zhou, Zhuang Yang, Xuemei Liu, Huimin Duan, Chao Shen*. The Host Protein CAD Regulates the Replication of FMDV through the Function of Pyrimidines’ De Novo Synthesis. Journal of Virology, 2023. DOI: /10.1128/jvi.00369-23.

2. Gu Meijia^#, Wu MingYu^#, Yuan Yuncong, Ho Po-Yu, Zhou Zhou, Zhao Engui*, Shen Chao*, Chen Sijie*. Isoquinolinium-based photosensitizers with aggregation-induced emission characteristics for highly efficient photodynamic combat of viruses. Materials Chemistry Frontiers, 2022, 6, 3042-3053. DOI: 10.1039/d2qm00630h.

3. Yuan, Yuncong, Xingran Wang, Jiadai Li, Lingling Han, Hang Du, Yidan Sun, Pu Yang, Zhou Zhou, Meijia Gu, Yang Lu, Chao Shen*. Single-Cell Sequencing Yields Insights in the Evolution of Foot-and-Mouth Disease Virus Persistent Infection. Frontiers in Cellular and Infection Microbiology, 2022, 12:940906.

4. Meijia Gu*, Huaqin Pan, Yuncong Yuan, Xuemin Zhou, Luojia Chen, Fang Fang, Liu Hu, Yaxuan Xie, Chao Shen*. Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identify Critical Biomarkers of COVID-19. Frontiers in Cellular and Infection Microbiology, 2022, 12: 882661.

5. Luojia Chen^#, Xingran Wang^#, Yuncong Yuan, Rui Hu, Qingrong Chen, Lijun Zhu, Meijia Gu*, Chao Shen*. Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications, Engineered Regeneration. 2022, 3(1): 59-72.

6. Gu Meijia, He Ti, Yuan Yuncong, Duan Suling, Li Xin*, Shen Chao*. Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer. Frontiers in Oncology. 2021,11: 4784.

7. Lingling Han#, Yuncong Yuan#, Jianjun Hu, Jiadai Li, Shumin Zhu, Pu Yang, Andi Cheng, Xinmei Li, Chao Shen*. Next-generation sequencing sheds light on the interaction between virus and cell during foot-and-mouth disease virus persistent infection. Veterinary Microbiology. 2021, 263: 109247.

8. Meijia Gu, Meimei Yang, Jing He, Sixuan Xia, Zhe Zhang, Yudong Wang, Congyi Zheng, Chao Shen*. A silver lining in cell line authentication: Short tandem repeat analysis of 1373 cases in China from 2010 to 2019. International Journal of Cancer. 2021, 1-7.

9. Libei Huang, Meijia Gu, Zhaoyu Wang, Tsz Wing Tang, Zonglong Zhu, Yuncong Yuan, Dong Wang, Chao Shen*, Ben Zhong Tang*, Ruquan Ye*. Highly Efficient and Rapid Inactivation of Coronavirus on Non‐Metal Hydrophobic Laser‐Induced Graphene in Mild Conditions. Advanced Functional Materials. 2021, 31, 2101195.

10. Meijia Gu, Jingxuan Liu, Meimei Yang, Mingmin Zhang, Jian Yang, Suling Duan, Xuxu Ding, Jie Liu, Chuguang Chen, Yundian Zeng, Chao Shen*. Advantages of a 21-loci short tandem repeat method for detection of cross- contamination in human cell lines. Gene. 2020, 763: 145048.

11. Yao Hao, Yao Huang, Jingyi Chen, Li Jiadai, Yuan Yuncong, Mingzhen Wang, Lingling Han, Xiu Xin, Hailong Wang, Danqing Lin, Fang Peng, Fang Yu, Congyi Zheng, Chao Shen*. Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling. Cell Proliferation. 2020, 53(8) , e12869.

12. Hailong Wang, Xiu Xin*, Congyi Zheng, Chao Shen*. Single-Cell Analysis of Foot-and-Mouth Disease Virus. Frontiers in Microbiology. 2020, 11:361.

13. Jiadai Li, Lingling Han, Yao Hao, Yuncong Yuan, Mingzhen Wang, Xiu Xin, Hailong Wang, Fang Yu, Congyi Zheng, Chao Shen*. Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection. Virologica Sinica. 2019, 35:52-63.

14. Meijia Gu, Chao Shen*. Novel cancer cell lines derived from primary breast tumors in Chinese patients. American Journal of Translational Research. 2018, 10(12):3956-3968.

15. Xiu Xin, Hailong Wang, Lingling Han, Mingzhen Wang, Hui Fang, Yao Hao, Jiadai Li, Hu Zhang, Congyi Zheng, Chao Shen*. Single-cell analysis of the impact of host-cell heterogeneity on infection with foot and mouth disease virus. Journal of Virology. 2018, 92(9), e00179-18.

16. Hailong Wang, Xiu Xin, Mingzhen Wang, Lingling Han, Jiadai Li, Yao Hao, Congyi Zheng, Chao Shen*. Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation. Archives of Virology, 2018, 163:1429–1438.

17. Lingling Han, Xiu Xin, Hailong Wang, Jiadai Li, Yao Hao, Mingzhen Wang, Congyi Zheng, Chao Shen*. Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome. Scientific Reports, 2018, 8:5074.

18. Yaqing Huang, Yuehong Liu, Congyi Zheng*, Chao Shen*. Investigation of Cross-Contamination and Misidentification of 278 Widely Used Tumor Cell Lines. PLOS ONE, 2017, 12(1): e0170384.

19. Wei Xiong, Jie Yang，Mingzhen Wang, Hailong Wang, Zhipeng Rao, Cheng Zhong, Xiu Xin，Lin Mo，Shujuan Yu, Chao Shen*, Congyi Zheng*. Vinexin β interacts with Hepatitis C Virus NS5A modulating its hyperphosphorylation to regulate viral propagation. Journal of Virology, 2015, 89(14):7385-7400.

20. Bing Yuan, Hui Fang, Chao Shen*, Zheng Congyi*. Expression of porcine Mx1 with FMDV IRES enhances the antiviral activity against foot-and-mouth disease virus in PK-15 cells. Archives of Virology. 2015, 160(8):1989-1999.