主要教育及工作经历

1978-82和86年  四川农业大学取得学士和硕士学位

1989-92  华西医科大学取得博士学位

1992-94  武汉大学生物（遗传）学博士后

1994.9-12 美国加州大学旧金山分校（UCSF）访问学习

1996.6-8    澳大利亚Latrobe 大学访问学习

1996.10-97.5  美国Louisiana州立大学访问学习

1998.11-99.11 法国人类遗传学研究所（CNRS）访问学习

2002.12-03.3  法国巴斯德研究所（Pasteur）访问学习

2006.5. 香港大学 客座教授

主要任职、获奖及荣誉

1996年起任武汉大学教授

1998年起评为博士生导师

2014年获珞珈杰出学者

2005年获教育部新世纪优秀人才计划

2006年享受国务院政府特殊津贴

SCI刊物Cell Biosci., Editorial Board Member

SCI刊物BMC Ecol.Evol., Editorial Board Member

SCI刊物BioMed Res.Intl., Editorial Board Member

SCI刊物Zebrafish, Editorial Board Member

国家科学技术奖评审专家

中国人类遗传资源管理专家组成员

国家实验细胞资源共享平台专家委员会委员

谈家桢遗传教育奖评审委员会委员

农业动物遗传育种与繁殖教育部重点实验室学术委员会委员

历任《遗传学报》、《遗传》、《动物学研究》和《农业生物技术学报》编委

第六届中国遗传学会动物遗传学专业委员会副主任、第八届教育教学委员会委员；第三届淡水生态与生物技术国家重点实验室学术委员会委员；第六届中国空间生命专业委员会委员等职。

曾获湖北省青年科技奖、中国遗传学会李汝祺优秀动物遗传学奖、湖北省自然科学二等奖等。

主要研究领域和兴趣

人类和小鼠等脊椎动物的发育从受精卵开始，经历早期胚胎发育与分化，器官形成与胎儿生长，直至完整生命体出生。我们主要探索脊椎动物胚胎发育与分化过程中所涉及的众多基因的时空表达与调控。通过进化时空和多个模式物种的比较研究，以及功能基因组、转录组、蛋白质组、转基因动物、基因敲除及生物信息技术等多种现代生命科学手段，研究基因-发育-进化等生命本质, 尤其关注胚胎发生、细胞分化、干细胞命运、生殖与发育等生命活动及其分子演化和分子病理机制。

研究资助

国家重点基础研究发展规划(973)、国家科技支撑计划、转基因重大专项、国家自然科学基金、教育部新世纪优秀人才计划、教育部科技研究重点项目和武汉市学科带头人计划等资助。

发表的论文（#并列第一作者，*通讯作者）

1. Cheng H.*, Shang D. and Zhou R.*, Germline stem cells in human, Signal Transduct. Target. Ther. 2022,7(1):345.

2. Cheng H.* and Zhou R.*, Decoding genome recombination and sex reversal. Trends in Endocrinology & Metabolism.2022, 33(3):175-185.

3. Cheng H.*, He Y.*, Zhou R.*, Swamp eel (Monopterus albus). Trends in Genetics, 2021, 37(12):1137-1138.

4. Zhang Y., Xu X., Hu M., Wang X., Cheng H.*, Zhou R.*, SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death Differ., 2021, 28, 1076-1090.

5. Xu X., Zhang Y., Cheng H.*, Zhou R.*, SPATA33 functions as a mitophagy receptor in mammalian germline. Autophagy, 2021, 17(5):1284-1286.

6. Shang D., Wang L., Klionsky DJ., Cheng H.*, Zhou R.*, Sex differences in autophagy-mediated diseases: toward precision medicine. Autophagy, 2021, 17(5):1065-1076.

7. Cheng Y., Lai F., Wang X., Shang D., Zou J., Luo M., Xia X., Cheng H.*, Zhou R.*, Srag regulates autophagy via integrating into a preexisting autophagy pathway in testis. Mol Biol Evol. 2021. 38(1):128-141.

8. Wang X., Lai F., Shang D., Cheng Y., Lan T., Cheng H.*, Zhou R.*, Cellular fate of intersex differentiation. Cell Death Dis., 2021, 12(4):388.

9. Li Z., Li H., Xu X., Wang L., Liu B., Zheng W., Lian L., Song Y., Xia X., Hou L., Cheng H.*, Zhou R.*, Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina. Cell Death Differ. 2020，27(2):556-572.

10. Cheng Y., Shang D., Luo M., Huang C., Lai F., Wang X., Xu X., Ying R., Wang L., Zhao Y., Zhang L., Long M., Cheng H.*, Zhou R.*. Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome. Cell Bioscience. 2020,10:67.

11. Zhao Y., Shang D., Ying R., Cheng H.*, Zhou R.*, An optimized base editor with efficient C-to-T base editing in zebrafish. BMC Biol. 2020;18(1):190.

12. Hong Q., Li C., Ying R., Lin H., Li J., Zhao Y., Cheng H.*, Zhou R.*, Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish. Protein Cell. 2019, 10(5):347-364.

13. Xu X., Shang D., Cheng H., Klionsky DJ., Zhou R.*, Gene essentiality of Tubgcp4: dosage effect and autophagy regulation in retinal photoreceptors. Autophagy. 2019, 15(10):1834-1837.

14. Sheng Y., Song Y., Li Z., Wang Y., Lin H., Cheng H.*, Zhou R.*, RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018; 25(5):918-934.

15. Song Y., Shang D., Cheng H.*, Zhou R.*, The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Autophagy. 2018; 14(4): 702-714.

16. Zhao X., Luo M., Li Z., Zhong P., Cheng Y., Lai F., Wang X., Min J., Bai M., Yang Y., Cheng H.*, Zhou R.*, Chromosome-scale assembly of the Monopterus genome. GigaScience. 2018;7(5):1-9.

17. Liu J., Shang D., Xiao Y., Zhong P., Cheng H.*, Zhou R.*, Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J. Biol. Chem. 2017; 292(39):16003-16013.

18. Luo M., Zhao X., Song Y., Cheng H.*, Zhou R.*, Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm. Autophagy. 2016;12(11):1973-1983.

19. Xiao Y., Gao M., Gao L., Zhao Y., Hong Q., Li Z., Yao J., Cheng H.*, Zhou R.*, Directed differentiation of zebrafish pluripotent embryonic cells to functional cardiomyocytes. Stem Cell Reports. 2016;7(3):370-82.

20.  Yuan J., Zhang Y., Sheng Y., Fu X., Cheng H.*, Zhou R.*, MYBL2 guides autophagy suppressor VDAC2 to the developing ovary to inhibit autophagy through a complex of VDAC2 /BECN1/ BCL2L1 in mammals. Autophagy, 2015, 11(7):1081-1098.

21. Fu X., Cheng Y., Yuan J., Huang C., Cheng H.*, Zhou R.*, Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum. Genet. 2015, 134(2):147-158.

22. Chen K., Huang C., Yuan J., Cheng H.*, Zhou R.*, Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol. 2014, 31(8):2194-211.

23. Zuo Z., Peng D., Yin X., Zhou X., Cheng H.*, Zhou R.*, Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves. Mol Biol Evol. 2013, 30(9):2087-98.

24. Hou Y., Yuan J., Zhou X., Fu X., Cheng H.*, Zhou R.*, DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi. PLoS Genet. 2012, 8(5):e1002716.

25. Zhou F., Zhao W., Zuo Z., Sheng Y., Zhou X., Hou Y., Cheng H.*, Zhou R.*, Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel. J. Biol. Chem. 2010, 285(47):37030-40.

26. Zhou X., Zuo Z., Zhou F., Zhao W., Sakaguchi Y., Suzuki T., Suzuki T., Cheng H.*, Zhou R.*, Profiling sex-specific piRNAs in zebrafish. Genetics. 2010,186(4):1175-85.

27. Ying M., Chen B., Tian Y., Hou Y., Li Q., Shang X., Sun J., Cheng H.*, Zhou R.*, Nuclear import of human sexual regulator DMRT1 is mediated by importin-β. BBA Mol. Cell Res. 2007, 1773(6):804-813.

28. Huang X., Guo Y., Shui Y., Gao S., Yu H., Cheng H.*, Zhou R.*, Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation during sex reversal of the rice field eel. Biol. Reprod. 2005, 73: 1017–1024.

29. Cheng H., Ying m., Tian Y., Guo Y., McElreavey K., Zhou R.*, Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cell Res. 2006, 16:389-393.

30. Zhou R., Bonneaud N., Yuan C-X., de Barbara P., Boizet B., Tibor G.S., Scherer Roeder R.G., Poulat F., Berta P.*, SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res. 2002, 30(14): 3245-52.

31. 周荣家，程汉华，编著《转基因动物技术与应用》，武汉大学出版社，1997

32. 周荣家等，译著《发育原理》，高等教育出版社，2009

33. 周荣家，人类性别是如何决定的？10000个科学难题-生物学卷, 科学出版社，2010

34. 周荣家，某些动物性别转换是如何发生的？10000个科学难题-生物学卷，科学出版社，2010