个人简介

2009年        中国科学院动物研究所，生态学专业，理学博士

2009-2012  美国密歇根大学生态与进化生物学系，博士后

2012-至今   武汉大学生命科学学院，教授

实验室网站：http://animal-evolution.whu.edu.cn/

研究概述

自然选择是现代生物学的核心理论，也是生物演化的关键驱动力。我们的研究领域是动物多样性与适应性分子演化，用自然选择理论解析动物物种多样性、性状多样性演化的分子基础。具体研究方向包括：(1）脊椎动物味觉基因的功能演化及其在食性多样性演化中的作用机制；（2）蝙蝠重要性状的分子或基因组演化；（3）青藏高原鸟类多样性保护及其适应性进化。

主持课题项目

1. 国家自然科学基金面上项目（32270436), 2023-2026；
2. 国家自然科学基金优秀青年科学基金（31722051), 2018-2020；

3. 国家拔尖人才项目 (210500002), 2018-2020；

4. 国家自然科学基金面上项目（31672272), 2017-2020；

5. 国家自然科学基金青年项目（31300313), 2014-2016；

6. 国家自然科学基金重大研究计划培育项目（91331115), 2014-2016.

7. 湖北省杰出青年基金（2019CFA075），2019-2021.

代表性论文（Selected Publications) (此处不再更新，最新论文及其PDF全文下载链接http://animal-evolution.whu.edu.cn/publications.htm)

1. Yan H^#, Jiao H^#, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K*, Chen Y*, and Zhao H* (2021). ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species.Nature Ecology & Evolution. 5(5):600-608.

2. Tian S#, Zeng J#, Jiao H, Zhang D, Zhang L, Lei CQ, Rossiter SJ, and Zhao H* (2023). Comparative analyses of bat genomes identify distinct evolution of immunity in Old World fruit bats. Science Advances. In press.

3. Hao X, Jiao H, Zou D, Li Q, Yuan X, Liao W, Jiang P, and Zhao H* (2023). Evolution of bitter receptor genes and ontogenetic dietary shift in a frog. PNAS. 120(8):e2218183120.

4. Jiao H^#, Xie HW^#, Zhang L^#, Zhuoma N, Jiang P, and Zhao H* (2021). Loss of sweet taste despite the conservation of sweet receptor genes in insectivorous bats. PNAS. 118(4):e2021516118.

5. Jiao H^#, Wang Q^#, Wang BJ, Li K, Lövy M, Nevo E, Li Q, Su W, Jiang P, and Zhao H* (2021). Local adaptation of bitter taste and ecological speciation in a wild mammal.Molecular Biology and Evolution. In press. DOI: 10.1093/molbev/msab205

6. Zou D, Tian S, Zhang T, Zhuoma N, Wu G, Wang M, Dong L, Rossiter SJ, and Zhao H* (2021). Vulture genomes reveal molecular adaptations underlying obligate scavenging and low levels of genetic diversity.Molecular Biology and Evolution. In press.

7. Zhao H* (2020). COVID-19 drives new threat to bats in China.Science. 367(6485):1436. DOI: 10.1126/science.abb3088 (Letter)

8. Wang K, Tian S, Galindo-González J, Dávalos LM, Zhang Y, and Zhao H* (2020). Molecular adaptation and convergent evolution of frugivory in Old World and neotropical fruit bats.Molecular Ecology. 29(22):4366-4381.

9. Wang BJ, Xia JM, Wang Q, Yu JL, Song Z, and Zhao H* (2020). Diet and adaptive evolution of alanine-glyoxylate aminotransferase mitochondrial targeting in birds.Molecular Biology and Evolution.37(3):786-798.

10. Jiao H^#, Zhang L^#, Xie HW, Simmons NB, Liu H, and Zhao H*(2019).Trehalase gene as a molecular signature of dietary diversification in mammals.Molecular Biology and Evolution.36:2171-2183.

11. Jiao H, Wang Y, Zhang L, Jiang P*, and Zhao H* (2018). Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats.Molecular Ecology. 27:4475–4488.

12. Wu J^#, Jiao H^#, Simmons NB, Lu Q*, and Zhao H* (2018). Testing the sensory tradeoff hypothesis in New World bats.Proceedings of the Royal Society B: Biological Sciences. 285:20181523. (Cover Story)

13. Zhang Y, Jiao Y, Jiao H,Zhao H*, and Zhu YX* (2017). Two-step functional innovation of the stem-cell factors WUS/WOX5 during plant evolution.Molecular Biology and Evolution. 3:640-653.

14. Li K^#, Hong W^#, Jiao H, Wang GD, Rodriguez KA, Buffenstein R, Zhao Y, Nevo E*, and Zhao H* (2015). Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax.PNAS. 112:11905-11910.

15. Zhao H, Li J, and Zhang J* (2015). Molecular evidence for the loss of three basic tastes in penguins.Current Biology. 25:R141-R142.

16. Hong W, and Zhao H* (2014). Vampire bats exhibit evolutionary reduction of bitter taste receptor genes common to other bats.Proceedings of the Royal Society B: Biological Sciences. 281: 20141079.

17. Zhao H*, and Zhang J* (2012). Mismatches between feeding ecology and taste receptor evolution: An inconvenient truth.PNAS. 109:E1464. (Letter to Editor)

18. Zhao H, Xu D, Zhang S*, and Zhang J* (2011). Widespread losses of vomeronasal signal transduction in bats.Molecular Biology and Evolution. 28:7-12.

19. Zhao H, Zhou Y, Pinto CM, Charles-Dominique P, Galindo-Gonzalez J, Zhang S*, and Zhang J* (2010). Evolution of the sweet taste receptor gene Tas1r2 in bats.Molecular Biology and Evolution. 27:2642-2650.

20. Zhao H, Yang JR, Xu H, and Zhang J* (2010). Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo.Molecular Biology and Evolution. 27:2669-2673.

21. Zhao H, Rossiter SJ*, Teeling EC*, Li C, Cotton JA, and Zhang S* (2009). The evolution of color vision in nocturnal mammals.PNAS. 106:8980-8985.