教育经历

1979-1983 华中农业大学，畜牧兽医学专业本科生

1983-1986 四川农业大学，动物遗传育种学专业硕士生

1990-1993 华西医科大学，生物化学与分子生物学专业博士生

主要工作经历与任职情况

1986－1990 华中农业大学，助教

1993－至今  武汉大学，讲师、副教授、教授、博士生导师

主要社会兼职

2008-2009  教育部科技奖励评审专家；

2014-至今  湖北省细胞生物学学会理事、教学与科普专业委员会主任

2013-至今  国家精品课程《生物化学》资源共享升级负责人

2000-2012  全国高考阅卷生物科目负责人（湖北省）

主要科研奖励和个人荣誉

1998年武汉大学首届珞珈青年赤子优秀奖；

2002年四川省科技进步奖一等奖（第六）；

2005湖北省自然科学二等奖（第二）；

2005年获批教育部新世纪人才计划；

2006年入选年度中国青年科技协会会员；

2005-2007年度武汉大学优秀女教工荣誉；

2008年武汉市三八红旗手称号；

2009年湖北省先进女教职工荣誉称号；

先后获得有武汉大学教学成果奖二等奖、本科生教学优秀质量奖、年度优秀导师奖；武汉大学生命科学学院本科生优秀导师奖、本科生优秀教学奖和教职工年度优秀评级。

主持课题项目

国家自然科学基金面上项目多项

留学回国基金

湖北省自然科学基金

教育部新世纪优秀人才培养计划基金项目

国家级精品资源共享课立项

973重大研究计划子项目（参与）

主要研究领域和兴趣

我们的研究领域是动物及人类分子细胞生物学。通过人类及多模式物种（主要是小鼠，斑马鱼和黄鳝）研究早期胚胎发育、分化和器官形成过程中所涉及的众多基因的时空表达与调控；研究基因-发育-进化等生命本质, 尤其关注生殖与发育、细胞分化、干细胞命运及小RNA等生命活动及其分子病理机制。

发表的论文（#并列第一作者，*通讯作者）

1. Cheng H.*, Shang D. and Zhou R.*, Germline stem cells in human, Signal Transduct. Target. Ther. 2022,7(1):345.

2. Cheng H.* and Zhou R.*, Decoding genome recombination and sex reversal. Trends in Endocrinology & Metabolism.2022, 33(3):175-185.

3. Cheng H.*, He Y.*, Zhou R.*, Swamp eel (Monopterus albus). Trends in Genetics, 2021, 37(12):1137-1138.

4. Zhang Y., Xu X., Hu M., Wang X., Cheng H.*, Zhou R.*, SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death Differ., 2021, 28, 1076-1090.

5. Xu X., Zhang Y., Cheng H.*, Zhou R.*, SPATA33 functions as a mitophagy receptor in mammalian germline. Autophagy, 2021, 17(5):1284-1286.

6. Shang D., Wang L., Klionsky DJ., Cheng H.*, Zhou R.*, Sex differences in autophagy-mediated diseases: toward precision medicine. Autophagy, 2021, 17(5):1065-1076..

7. Cheng Y., Lai F., Wang X., Shang D., Zou J., Luo M., Xia X., Cheng H.*, Zhou R.*, Srag regulates autophagy via integrating into a preexisting autophagy pathway in testis. Mol Biol Evol. 2021. 38(1):128-141.

8. Wang X., Lai F., Shang D., Cheng Y., Lan T., Cheng H.*, Zhou R.*, Cellular fate of intersex differentiation. Cell Death Dis., 2021, 12(4):388.

9. Li Z., Li H., Xu X., Wang L., Liu B., Zheng W., Lian L., Song Y., Xia X., Hou L., Cheng H.*, Zhou R.*, Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina. Cell Death Differ. 2020，27(2):556-572.

10. Cheng Y., Shang D., Luo M., Huang C., Lai F., Wang X., Xu X., Ying R., Wang L., Zhao Y., Zhang L., Long M., Cheng H.*, Zhou R.*. Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome. Cell Bioscience. 2020,10:67.

11. Zhao Y., Shang D., Ying R., Cheng H.*, Zhou R.*, An optimized base editor with efficient C-to-T base editing in zebrafish. BMC Biol. 2020;18(1):190.

12. Hong Q., Li C., Ying R., Lin H., Li J., Zhao Y., Cheng H.*, Zhou R.*, Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish. Protein Cell. 2019, 10(5):347-364.

13. Sheng Y., Song Y., Li Z., Wang Y., Lin H., Cheng H.*, Zhou R.*, RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018; 25(5):918-934.

14. Song Y., Shang D., Cheng H.*, Zhou R.*, The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Autophagy. 2018; 14(4): 702-714.

15. Zhao X., Luo M., Li Z., Zhong P., Cheng Y., Lai F., Wang X., Min J., Bai M., Yang Y., Cheng H.*, Zhou R.*, Chromosome-scale assembly of the Monopterus genome. GigaScience. 2018;7(5):1-9.

16. Liu J., Shang D., Xiao Y., Zhong P., Cheng H.*, Zhou R.*, Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J. Biol. Chem. 2017; 292(39):16003-16013.

17. Luo M., Zhao X., Song Y., Cheng H.*, Zhou R.*, Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm. Autophagy. 2016;12(11):1973-1983.

18. Xiao Y., Gao M., Gao L., Zhao Y., Hong Q., Li Z., Yao J., Cheng H.*, Zhou R.*, Directed differentiation of zebrafish pluripotent embryonic cells to functional cardiomyocytes. Stem Cell Reports. 2016;7(3):370-82.

19. Yuan J., Zhang Y., Sheng Y., Fu X., Cheng H.*, Zhou R.*, MYBL2 guides autophagy suppressor VDAC2 to the developing ovary to inhibit autophagy through a complex of VDAC2 /BECN1/ BCL2L1 in mammals. Autophagy, 2015, 11(7):1081-1098.

20. Fu X., Cheng Y., Yuan J., Huang C., Cheng H.*, Zhou R.*, Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum. Genet. 2015, 134(2):147-158.

21. Chen K., Huang C., Yuan J., Cheng H.*, Zhou R.*, Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol. 2014, 31(8):2194-211.

22. Zuo Z., Peng D., Yin X., Zhou X., Cheng H.*, Zhou R.*, Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves. Mol Biol Evol. 2013, 30(9):2087-98.

23. Hou Y., Yuan J., Zhou X., Fu X., Cheng H.*, Zhou R.*, DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi. PLoS Genet. 2012, 8(5):e1002716.

24. Zhou F., Zhao W., Zuo Z., Sheng Y., Zhou X., Hou Y., Cheng H.*, Zhou R.*, Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel. J. Biol. Chem. 2010, 285(47):37030-40.

25. Zhou X., Zuo Z., Zhou F., Zhao W., Sakaguchi Y., Suzuki T., Suzuki T., Cheng H.*, Zhou R.*, Profiling sex-specific piRNAs in zebrafish. Genetics. 2010,186(4):1175-85.

26. Ying M., Chen B., Tian Y., Hou Y., Li Q., Shang X., Sun J., Cheng H.*, Zhou R.*, Nuclear import of human sexual regulator DMRT1 is mediated by importin-β. BBA Mol. Cell Res. 2007, 1773(6):804-813.

27. Huang X., Guo Y., Shui Y., Gao S., Yu H., Cheng H.*, Zhou R.*, Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation during sex reversal of the rice field eel. Biol. Reprod. 2005, 73: 1017–1024.

28. Cheng H., Ying m., Tian Y., Guo Y., McElreavey K., Zhou R.*, Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cell Res. 2006, 16:389-393.

29. 主编 张楚富，副主编 程汉华 刘德立 生物化学原理 高等教育出版社 2011年

30. 程汉华主编 生物化学数字课程 高等教育出版社2018年