学习经历

2005/09-2009/06  法国巴黎第十一大学，博士

2002/09-2005/07  华东师范大学，硕士

1996/09-2000/07  烟台师范学院，学士

主要工作经历与任职情况

2019/01 - 今        武汉大学生命科学学院, 副研究员

2016/01 - 2018/12  中国科学院上海植物生理生态研究所，副研究员

2009/07 - 2015/12  中国科学院上海植物生理生态研究所，助理研究员

主要社会兼职

2023年起，任武汉生物物理学会理事

研究内容

1) RNA剪接在神经系统和生殖发育中的调控作用;

2) 环状RNA的形成、调控及其在个体发育与疾病中的功能；

多拷贝/变体剪接体snRNA基因对发育与疾病调控机制研究。

主持课题项目

1) 国家自然科学基金面上项目(31570821), 果蝇发育中的U12型剪接调控, 2016-2019、65万元、已结题、主持

2) 国家自然科学基金青年项目(31000340), DOA激酶与SRm160互作对RNA剪接的影响及其在发育调控中的作用, 2011-2013、19万元、已结题、主持

中国科学院上海生命科学研究院优秀青年人才领域前沿项目(2010KIP307), MAPK信号通路对果蝇发育中SRm160功能的调节作用, 2010-2012、15万元、已结题、主持

发表的论文（^#并列第一作者，^*通讯作者）

1. Fan YJ ^#*, Ding Z^#, Zhang Y^#, Su R, Yue JL, Liang AM, Huang QW, Meng YR, Li M, Xue Y and Xu YZ*. Sex-lethal regulates back-splicing and generation of the sex-differentially expressed circular RNAs. Nucleic Acids Research, 2023, 51(10): 5228-5241.

2. Ding Z^#, Meng YR, Fan YJ and Xu YZ*. Roles of minor spliceosome in intron recognition and the convergence with the better understood major spliceosome. WIREs RNA, 2023, 14(1): e1761.

3. Zhang B, Ding Z, Li L, Xie LK, Fan YJ, Xu* YZ. Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila. PLoS Genetics, 2021, 17(11): e1009861.

4. Pang TL, Ding Z, Liang SB, Li L, Zhang B, Zhang Y, Fan YJ, Xu YZ. Comprehensive identification and alternative splicing of microexons in Drosophila. Frontiers in Genetics, 2021, 12: 642602.

5. Li L, Ding Z, Pang T-L, Zhang B, Li C-H, Liang A-M, Wang Y-R, Zhou Y, Fan YJ* and Xu YZ*. Defective Minor Spliceosomes Induce SMA-associated phenotypes through Sensitive Intron-Containing Neural Genes in Drosophila. Nature Communications, 2020, 11(1): 5608.

6. Shao W, Ding Z, Zheng ZZ, Shen JJ, Shen YX, Pu J, Fan YJ, Query CC* and Xu YZ*. Prp5–Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription. Nucleic Acids Research, 2020, 48: 5799-5813.

7. Lv M^#, Yao Y^#, Li F, Xu L, Yang L, Gong Q, Xu YZ, Shi Y, Fan YJ* and Tang Y*. Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila. Nucleic Acids Research, 2019, 47(6): 3142-3157.

8. Qiu C^#, Zhang Y^#, Fan YJ^#, Pang TL, Su Y, Zhan S* and Xu YZ*. HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. Journal of Molecular Cell Biology, 2019, 11(2): 170–181.

9. Zheng ZZ, Sun X, Zhang B, Pu J, Jiang ZY, Li M, Fan YJ and Xu YZ* (2019) Alternative splicing regulation of doublesex gene by RNA-binding proteins in the silkworm Bombyx mori. RNA Biology, 16: 809-820.

10. Gao JL^#, Fan YJ^#, Wang XY^#, Zhang Y, Pu J, Li L, Shao W, Zhan S, Hao J and Xu YZ^*. A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila. Genes & Development, 2015, 29(7):760-71.

11. Fan YJ*, Gittis AH, Juge F, Qiu C, Xu YZ and Rabinow L*. Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila, Genetics, 2014, 197(4): 1251-1265.

12. Yang F, Wang XY, Zhang ZM, Pu J, Fan YJ, Zhou J, Query CC and Xu YZ^*. Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Research, 2013, 41(8), 4660-4670.

13. Fan YJ, Schlierf M, Gaspar AC, Dreux C, Kpebe A, Chaney L, Mathieu A, Hitte C, Grémy O, Sarot E, Horn M, Zhao YL, Kinzy TG and Rabinow L. Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability, Genetics, 2010, 184(1):141-154.

14. An CG, Weng XL, Xu YZ, Fan YJ^* and Zhao YL^*. Histological and ultrastructural studies on the male reproductive system and spermatogenesis in the red claw crayfish, Cherax quadricarinatus, Journal of Crustacean Biology, 2011, 31(2), 223-230.