学习经历：

2002.9-2005.3，中国科学院动物研究所，博士

1997.9-2000.7，北京师范大学，生命科学学院，硕士

1993.9-1997.7，北京师范大学，生物系，学士

主要工作经历与任职情况：

2023.12至今，武汉大学生命科学学院，教授

2021.1-2023.11，中国科学院生物物理研究所，副研究员

2009.1-2021.1，中国科学院动物研究所，副研究员，创新研究员（2016-2019）

2016.9-2017.2，Babraham Institute，访问学者

2006.6-2008.6，University of British Columbia，博士后

2004.6-2009.1，中国科学院动物研究所，助理研究员

2000.7-2004.6，中国科学院动物研究所，研究实习员

主要科研奖励和个人荣誉：

2014年度国家优秀青年科学基金获得者

2011年国家人口和计划生育委员会优秀科技成果奖一等奖，第四完成人

2017年全国妇幼健康科学技术奖二等奖，第四完成人

研究内容：

主要从事细胞命运决定、发育与疾病发生的表观遗传机理研究，重点关注表观遗传变异尤其是组蛋白变体突变相关疾病的致病机制。

主持课题项目：

国家自然科学基金面上/青年项目（2023-2026; 2019-2022; 2017-2020; 2013-2016; 2010-2012; 2008-2010; 2005），项目负责人

国家重点研发计划项目（2023-2028），项目骨干

北京市自然科学基金面上项目（2019-2021），项目负责人

国家自然科学基金国际合作与交流项目（中加健康研究合作计划）（2012-2014），项目负责人

国家重点基础研究发展计划（973计划）（2011-2015），项目骨干

中国科学院知识创新工程领域前沿项目（2010-2012），项目负责人

中国科学院院长基金特别支持项目（2009-2012），项目负责人

发表的论文（^#并列第一作者，^*通讯作者）：

1. 曹红, 吴迪^#, 魏瑜^#, 林海燕*，李国红*. 染色质结构蛋白变异与人类疾病. 中国科学: 生命科学, 2023, 53, 1575-1594.

2. Liu Y, Du M, Lin HY*. Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization. J Cell Mol Med, 2021, 25(16), 7690-7708.

3. Lin HY, Song G, Lei F, Li D, Qu Y. Avian corticosteroid-binding globulin: biological function and regulatory mechanisms in physiological stress responses. Front Zool, 2021, 18(1), 22.

4. Zheng R, Li Y, Sun H, Lu X, Sun BF, Wang R, Cui L, Zhu C, Lin HY*, Wang H. Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion. Reproduction, 2017, 153(1), 35-48.

5. Lu X, He Y, Zhu C, Wang H, Chen S*, Lin HY*. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta, 2016, 39, 45-54.

6. Lin W, Zhang J^#, Lin HY^#, Li Z^#, Sun X, Xin D, Yang M, Sun L, Li L, Wang H, Chen D*, Sun Q*. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun, 2016, 7, 11848.

7. Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adh Mig, 2016, 10(1-2), 39-55.

8. Lei JH, Yang XK, Peng S, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab, 2015, 100(5), 1819-1827.

9. Zhou Z, Wang R, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta, 2014, 35(11), 907-918.

10. Wang R, Dang YL, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod, 2014, 90(6), 117. (cover story)

11. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis, 2013, 4, e593.

12. Zhang S, Lin HY^#, Kong S^#, Wang S, Wang H, Wang H*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med, 2013, 34(5), 939-980. (invited review)

13. Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab, 2012, 97(4), E678-E686.

14. Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem, 2012, 113(10), 3266-3275.

15. Li Y, Wu L, Lei JH, Zhu C, Wang H, Yu XG*, Lin HY*. Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci, 2012, 55(8), 699-708.

16. Lin HY*, Muller YA, Hammond GL*. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol, 2010, 316(1), 3-12. (invited review)

17. Lin HY, Underhill C, Gardill BR, Muller YA, Hammond GL*. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem, 2009, 284(2), 884-896.

18. Yang Q, Chen SP, Zhang XP, Wang H, Zhu C, Lin HY*. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem, 2009, 57(6), 605-612.

19. Lin HY, Yang Q, Wang H, Qi JG, Zhang H, Wang HX, Tsang BK, Zhu C*. Involvement of SMAD4, but not of SMAD2, in transforming growth factor-β1-induced trophoblast expression of matrix metalloproteinase-2. Front Biosci, 2006, 11, 637-646.

20. Lin HY, Zhang H, Yang Q, Wang HX, Wang H, Chai KX, Chen LM*, Zhu C*. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. J Histochem Cytochem, 2006, 54(10), 1139-1147.

21. Lin HY, Qian D, Zhang X, Liu GY, Wang H, Zhu C*. Gene expression of transforming growth factor-β receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Life Sci, 2006, 78(23), 2669-2675.

22. Lin HY, Wang H, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C*. Expression of Smad2 and Smad4, transforming growth factor-β signal transducers, in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci, 2004, 80(3-4), 303-316.

23. Lin HY, Wang H, Zhu C*. The Smad pathway in transforming growth factor-beta signaling. Sci China C Life Sci, 2003, 46(5), 449-463.