教育经历/Education

1989.09-1995.01：美国Rutgers-新泽西州立大学，博士

                              Rutgers University, PhD

1986.09-1989.07：北京大学，硕士

                              Peking University, Master's Degree

1982.09-1986.07：北京大学，学士

                              Peking University, Bachelor's Degree

工作经历/Professional Experience

2015.09 - 至今：    武汉大学生命科学学院

                              College of Life Sciences, Wuhan University

2003.07-2015.08：中科院上海生科院营养科学研究所

                              Institute for Nutritional Sciences, Shanghai 

                              Institutes of Biological Sciences, Chinese Academy of Sciences

2000.11-2003.07：美国加州AlleCure/Mannkind生物技术公司

                              AlleCure/Mankind Corp., CA, USA

1995.03-2000.10：美国加州大学Santa Barbara分校分子、细胞与发育生物学系

                              Department of MCDB, University of California at Santa Barbara, CA, USA

社会兼职/Social Part-time Jobs

2012年 - 至今：J. Biol. Chem.杂志，编委

                         Journal of Biological Chemistry, Editorial Board Member

奖励荣誉/Awards and Honors

2004年 中科院“百人计划”择优支持

2009年 国家杰出青年科学基金

2009年 明治乳业生命科学优秀奖

2010年 上海市优秀学科带头人

2010年 国家自然科学基金委创新群体骨干

2011年 国务院政府特殊津贴

2011年 药明康德生命化学研究奖

2012年 国家重大科学研究973计划首席科学家

2012年 上海市领军人才

研究方向/Research Fields

1) 细胞应激与糖脂代谢紊乱的分子机制

The molecular mechanisms linking cellular stress pathways and metabolic dysfunctions

2) 内质网应激与免疫炎性疾病的分子基础

ER stress in the molecular pathogenesis of inflammatory diseases

研究概述/Research Description

致力于研究糖脂代谢调控的生理学机制和慢性炎性疾病的病理学基础。利用动物模型，在生理学水平上探索营养失衡、内质网应激与代谢紊乱的机制关联，深入了解免疫炎性疾病发生发展的分子病理学基础，为肥胖、2型糖尿病、脂肪性肝炎及衰老相关慢性疾病的防治探寻新的干预靶标。

Our research aims to elucidate the molecular mechanisms that link overnutrition, endoplasmic reticulum (ER) stress and metabolic/inflammatory disorders. Employing animal models, we attempt to dissect the physiological actions of the IRE1α arm of the unfolded protein response (UPR) in nutrient-sensing, metabolic control and immune homeostasis. Our studies will provide new insights into the pathogenic mechanisms underlying obesity, type 2 diabetes, NASH and other aging-related chronic inflammatory diseases.

科研项目/Rresearch Project

2021.01-2025.12 国家自然科学基金创新研究群体项目，脂代谢的稳态调控与重编程，骨干

2019.09-2024.08 国家科技部重点研发计划，应激对组织器官代谢稳态和发育的调控作用与机制，主持

2019.01-2022.12 国家自然科学基金重大研究计划，内质网应激感应分子IRE1α的代谢性激活在代谢稳态中的调控作用与机制，主持

2017.01-2021.12 国家自然科学基金重大项目，介导脂代谢可塑性的重要细胞器及其调控机制，主持

代表性学术论文/Selected Publications

1. Chen Y, Wu Z, Huang S, Wang X, He SJ, Liu L, Hu Y, Chen L, Chen P, Liu S, He SQ, Shan B, Zheng L, Duan S, Song Z, Jiang L, Wang QA, Gan Z, Song BL, Liu J, Rui LY, Shan M, Liu Y*. (2022) Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. Nat Metab. 4(9):1166-1184.

2. Li Y, Huang S, Wang J, Dai J, Cai J, Yan S, He S, Wang P, Jianmiao Liu J, Liu Y*. (2022) Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis. J Biol Chem. 298(6):101997.

3. Cai J, Zhang X, Chen P, Li Y, Liu S, Liu Q, Zhang H, WuZ, Song K, Liu J, Shan B*,Liu Y*. (2022)The ER stress sensor inositol-requiring enzyme 1αin Kupffer cells promotes hepatic ischemia-reperfusion injury.J Biol Chem.298(1):101532.

4. He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z,Liu Y*. (2021) IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay.J Clin Invest. 131(17):e143737.

5. Zhao P, Huang P, Xu T, Xiang X, Sun Y, Liu J, Yan C, Wang L, Gao J, Cui S, Wang X, Zhan L, Song H, Liu J, Song W*,Liu Y*. (2021) Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila.iScience. 24(8):102819.

6. Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL,Liu Y, Chen XW*, Gan Z*. (2019) Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis.Proc Natl Acad Sci U S A. 116(24):11776-11785.

7. Huang S, Xing Y. andLiu Y*.(2019) Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease.J Biol. Chem.294(49) 18726–18741. (Review)

8. Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao G, Ke Z,Liu Y*, Liu J*. (2019) IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.Cell Death Dis.10(11):800.

9. Wu Y,Shan B, Dai J, Xia Z, Cai J, Chen T, Lv S, Feng Y, Zheng L, Wang Y, Liu J, Fang J, Xie D, Rui L, Liu J,Liu Y*. (2018)Dual Role for Inositol-requiring Enzyme 1α in Promoting the Development of Hepatocellular Carcinoma during Diet-induced Obesity.Hepatology68:533-546.

10. Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ*,Liu Y*.(2017)The Metabolic ER Stress Sensor IRE1α Suppresses Alternative Activation of Macrophages to Impair Energy Expenditure in Obesity.Nat Immunol.18:519-529.

    (Highlighted inNews and Views,Nature Immunol.18:479-480, 2017;Preview,Mol Cell66:731-733, 2017;Nat Rev Immunol.17:277, 2017;Nat Rev Endocrinol.13:315, 2017)

11. Xiao Y,Xia T,Yu J,Deng Y,Liu H,Liu B,Chen S,Liu Y*,Guo F*. (2016) Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure.Open Biol.6(8). pii: 160131.

12. Wu J, Yang L, Li S, Huang P,Liu Y*, Wang Y*, Tang H*. (2016) Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice.J Proteome Res. 15:2299-308.

13. Qiu Y*, Shan B, Yang L,Liu Y*. (2016) Adipose tissue macrophage in immune regulation of metabolism.Sci China Life Sci.59:1232-1240. (Review)

14. Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L,Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses.J Hepatol.62:590-98.

15. Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M,Liu Y*, Fang J*. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.J Biol Chem.290:15327-36.

16. Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z,Liu Y*, Jia WP*. (2014) Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis.J Biol Chem. 289:29751-65.(Selected as one of theBest JBC Papers of the Year)

17. Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*,Liu Y*.(2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.Cell Res.24:1137-40.

18. Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L,LiuY*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Nat Commun.5:3528.

19. Zhang Q,Liu B,Cheng Y,Meng Q,Xia T,Jiang L,Chen S,Liu Y*,Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure.J Biol Chem.289:1779-87.

20. Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z,LiuY*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice.Nat Commun.4:2163.

21. Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L,Liu Y*. (2012)A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.J Biol Chem.287(45):37973-85.

22. Yu Y,Sun Y,He S,Yan C,Rui L,Li W,Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Mol Cell Biol.32:3610-23.

23. Yang L,Huang P,Li F,Zhao L,Zhang Y,Li S,Gan Z,Lin A,Li W,Liu Y*.(2012) c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.PLoS One7:e48611.

24. Zhou B,Yang L,Li S,Huang J,Chen H,Hou L,Wang J,Green CD,Yan Z,Huang X,Kaeberlein M,Zhu L,Xiao H,Liu Y* andHan JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions.Proc. Natl. Acad.Sci. U.S.A. Plus.109:E1201-9.

25. Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W andLiu Y*. (2011) PKA Phosphorylation Couples HepaticIRE1αto Glucagon Signaling in Glucose Metabolism.Proc. Natl. Acad.Sci. U.S.A.108:15852-7.

26. Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*,Liu Y*. (2010)Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.FASEB J.24:3720-32.

27. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W,Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice.J. Lipid Res.51:2516-26.

28. You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* andLiu Y*. (2010) Tyr⁹⁸⁵signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance.Mol. Cell. Biol. 30:1650-9.

    (Highlighted byEditor’s Choice,Science139, 141, 2010 andScience Signaling3, ec95, 2010)

29. Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y,Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.Cell Metab. 11:427-37.

30. Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z,Liu Y*. (2010) Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.Nutr Metab.(Lond)7:59.

31. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*,Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells.Sci. Signal. 3, ra7.

32. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W andLiu Y*.(2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.Hepatology. 49:1166-75.

33. Jiang L, Wang Q, Yu Y, Zhao F, Huang P, Zeng R, Qi RZ, Li W andLiu Y*. (2009) Leptin Contributes to the Adaptive Responses of Mice to High-fat Diet Intake through Suppressing the Lipogenic Pathway.PLoS One4:e6884.

34. Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,Liu Y*.(2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.Proc. Natl. Acad.Sci. U.S.A.105: 18619-24.

    (Highlighted byNature China, 2008)

35. Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H,Liu Y*, Lin X*.(2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people.J. Clin. Endocr. Metab.92:4827-34.

36. Gan Z, Zhao L, Yang L,Huang P, Zhao F, Li W,Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells.J. Biol. Chem.281:33386-94.