学习经历

2004--2008     武汉大学生命科学学院生物学专业，理学学士

　　　　　　　武汉大学经济管理学院（第二学位），管理学学士

2008--2013　 武汉大学生命科学学院细胞生物学专业，理学博士；导师：舒红兵 院士

主要工作经历与任职情况

2013--2015   武汉大学生命科学学院，师资博士后

2015--2017   武汉大学生命科学学院，讲师

2016--2017   MD Anderson Cancer Center, USA；导师：陈俊杰 教授

2017--至今    武汉大学生命科学学院，副教授

主要科研奖励和个人荣誉

2022 国家高层次青年人才

2021 湖北省青年拔尖人才

2015 国家自然科学奖二等奖(排名第五)

2015 湖北省科技晨光计划

2014 教育部自然科学奖一等奖(排名第五)

2014 湖北省优秀博士论文奖

2011 吴瑞奖，吴瑞基金会，美国

2011 教育部学术新人奖

主持课题项目

国家青年拔尖人才项目（主持），2022.10-2025.10

国家自然科学基金面上项目（主持），项目编号32270757，2023.01-2026.12

湖北省自然科学基金面上项目（主持），项目编号2022CFB144，2022.10-2024.09

中央高校自主科研项目拔尖人才培育项目（主持），2042022kf1192，2022.05-2024.05

湖北省青年拔尖人才项目（主持），2021.12-2024.12

国家自然科学基金面上项目（主持），项目编号32070773，2021.01-2024.12

国家重点实验室开放基金（主持），项目编号 SKLVEB2020KFKT002，2021.01-2022.12

中央高校自主科研项目学科交叉类（主持），项目编号2042019kf0204，2019.01-2020.12

国家自然科学基金面上项目（主持），项目编号31870870，2019.01-2022.12

湖北省自然科学基金—群体创新项目（项目骨干），项目编号2018CFA016，2018.01-2020.12

国家自然科学基金青年基金（主持），项目编号31400747，2015.01-2017.12

湖北省青年科技晨光计划（主持），2016.02-2018.02

湖北省自然科学基金面上项目（主持），项目编号2015CFB414，2015.01-2016.12

国家博士后基金面上项目一等资助（主持），项目编号2014M560623，2014.05-2015.06

中央高校自主科研项目青年项目（主持），项目编号2042014kf0013，2014.03-2015.12

国家自然科学基金重点项目（项目骨干），项目编号31830024，2019.01-2023.12

国家自然科学基金重点项目（项目骨干），项目编号31630045，2017.01-2021.12

国家科技部青年863项目（项目骨干），项目编号2015AA020939，2015.01-2017.12

发表论文（#第一作者，*通讯作者）

1. 通讯作者或第一作者论文

1. Xu Yanran#, Shi Mengling#, Zhang Yu#, Kong Na, Wang Cong, Xiao Yifeng, Du Shishen, Zhu Qiyun, Lei Caoqi*. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. PNAS, 2022, doi.org/10.1073/pnas.2122805119.

2. Zeng Yan, Xu Shuai, Wei Yanli, Zhang Xuefeng, Wang Qian, Jia Yane, Wang Wanbing, Han Lu, Chen Zhaoshan, Wang Zhengxiang, Zhang Bo, Chen Hualan, Lei Caoqi*, Zhu Qiyun*. The PB1 Protein of Influenza A Virus Inhibits the Innate Immune Response by Targeting MAVS for NBR1-Mediated Selective Autophagic Degradation. Plos Pathogens, 2021. doi.org/10.1371/journal.ppat.1009300

3. Xu Yanran#, Lei Caoqi*. TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses. Frontiers in Immunology, 2021. doi.org/10.3389/fimmu.2020.608976

4. Wei Yanli#, Zeng Yan#, Zhang Xuegang, Xu Shuai, Wang Zhengxiang, Du Yingying, Zhang Bo, Lei Caoqi*, Zhu Qiyun*. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. Journal of Virology, 2020, 23;94(24):e01640-20

5.  Zhong Xuan#, Feng Lu, Xu Wenhua, Wuxin, Ding Yidi, Zhou Yan, Lei Caoqi*, Shu Hongbing*. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating its ligand binding. Cellular & Molecular Immunology, 2020, 17(7):741-752.

6. Lei Caoqi#*, Wu Xin#, Zhong Xuan, Jiang Lu, Zhong Bo, Shu Hongbing*. USP19 inhibits TNFa- and IL-1b-triggered NF-kB activation by deubiquitinating TAK1. Journal of Immunology, 2019, 203(1):259-268.

7. Chen Zhen#, Lei Caoqi#, Wang Chao, Li Nan, Mrinal Srivastava, Tang Mengfan, Zhang Huimin, Choi Jongmin, Jung Sungyun, Qin Jun, Chen Junjie*. Global Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics. Nature Communications, 2019, 10: 104

8. Wang Junyong#, Zeng Yan, Xu Shuai, Yang Jiayun, Wang Wanbing, Ge Jinying, Yin Lei, Wang Zhengxiang, Han Lu, Cui Xiaole, Zhong Bo, Shu Hongbing, Chen Hualan, Lei Caoqi*, Zhu Qiyun*, A naturally occurring deletion in the effector domain of H5N1 influenza virus nonstructural protein 1 regulates viral fitness and host innate immunity. Journal of Virology, 2018, 92(11): e00149-18

9. Wang Junyong#, Lei Caoqi*, Ji Yanhong, Zhou Hongbo, Ren Yujie, Peng Qianqian, Zeng Yan, Jia Yane, Ge Jinying, Zhong Bo, Li Yu, Wei Jianzhong, Shu Hongbing, Zhu Qiyun*, Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-beta Signaling Pathways by Targeting VISA. Journal of Immunology, 2016, 197(12):4704-4713.

10. Lei Caoqi#, Zhang Yu, Li Mi, Jiang Liqun, Zhong Bo, Kim Yonghao, Shu Hongbing*, ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses. Journal of Innate Immunity, 2015, 7(2):153-164.

11. Lei Caoqi#, Zhang Yu, Xia Tian, Jiang Liqun, Zhong Bo, Shu Hongbing*, FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. Journal of Biological Chemistry, 2013, 288(18):12596-12604.

12. Lei Caoqi#, Zhong Bo, Zhang Yu, Zhang Jing, Wang Shuai, Shu Hongbing*， Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity, 2010, 33(6):878-889.

2. 参与发表论文

1. Li Chen, Feng Lu, Luo Weiwei, Lei Caoqi, Li Mi, Shu Hongbing*, The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response. Cell Discovery, 2021

2. Zhong Xuan#, Feng Lu, Zang Ru, Lei Caoqi, Yang Qing, Shu Hongbing*. ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response. Plos Pathogens, 2020

3. Chen Zhen#, Wang Chao, Lei Caoqi, Xu Feng, Li Chen, Sung Yunjung, Qin Jun, Chen Junjie*. Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3. Journal of Proteome Research, 2020

4. Liao Chenyang#, Lei Caoqi, Shu Hongbing*. PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA. Cellular & Molecular Immunology, 2020.

5. Wu Xin#, Lei Caoqi, Xia Tian, Zhong Xuan, Yang Qing, Shu Hongbing*. Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination. Nature Communications, 2019.

6. Lian Huan, Zang Ru, Ye Wen, Hu Mingming, Chen Yundan, Zhang Xianan, Guo yi, Lei Caoqi, Yang Qing, Luo Weiwei, Li Shu*, Shu Hongbing*, The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors, Immunity, 2018, 49(3):438-448.

7. Lian Huan, Wei Jing, Zang Ru, Ye Wen, Yang Qing, Zhang Xianan, Chen Yundan,  Fu Yuzhi, Hu Mingming, Lei Caoqi, Luo Weiwei, Li Shu*, Shu Hongbing*, ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. Nature Communications, 2018, 9(1):3349.

8. Ye Wen, Hu Mingming, Lei Caoqi, Zhou Qian, Lin Hen, Sun Mingshun, Shu Hongbing*, TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. Journal of Immunology, 2017, 199(5):1856-1864.

9. Jiang Liqun, Xia Tian, Hu Yunhong, Sun Mingshun, Yan Shuang, Lei Caoqi, Shu Hongbing, Guo Jihua, Liu Yu*, IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cellular & Molecular Immunology, 2017.

10. Li Shun, Zhu Mingzhu, Pan Ruangang, Fang Ting, Cao Yuanyuan, Chen Shuliang, Zhao Xiaolu, Lei Caoqi，Guo Lin, Chen Yu, Li Chunmei, Eija Jokitalo, Yin Yuxin, Shu Hongbing, Guo Deying*, The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology, 2016, 17(3):241-249.

11. Li Dan, Yang Wenping, Yang Fan, Liu Huanan, Zhu Zixiang, Lian Kaiqi, Lei Caoqi, Li Shu, Liu Xiangtao, Zheng Haixue*, Shu Hongbing*, The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-beta signaling pathway. FASEB Journal, 2016, 30(5):1757-1766.

12. Li Dan, Lei Caoqi, Xu Zhisheng, Yang Fan, Liu Huanan, Zhu Zixiaong, Li Shu, Liu Xiangtao, Shu Hongbing*, Zheng Haixue*, Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-beta signaling pathway. Scientific Reports, 2016, 6:21888.

13. Hu Yunhong, Zhang Yu, Jiang Liqiong, Wang Shuai, Lei Caoqi, Sun Mingshun, Shu Hongbing, Liu Yu*, WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Reports, 2015, 16(4):447-55.

14. Zhang Yu, Lei Caoqi, Hu Yunhong, Xia Tian, Li Mi, Zhong Bo, Shu Hongbing*, Kruppel-like factor 6 is a co-activator of NF-kappaB that mediates p65-dependent transcription of selected downstream genes. Journal of Biological Chemistry, 2014, 289(18):12876-12885.

15. Liu Zhigang, Wu Shuwen, Lei Caoqi, Zhou Qian, Li Shu, Shu Hongbing, Wang Yanyi*, Heat shock cognate 71 (HSC71) regulates cellular antiviral response by impairing formation of VISA aggregates. Protein & Cell, 2013, 4(5):373-382.

16. Zhong Bo, Zhang Lu, Lei Caoqi, Li Ying, Mao Aiping, Yang Yan, Wang Yanyi, Zhang Xiaolian, Shu Hongbing*, The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity, 2009, 30(3):397-407.

17. Zhong Bo, Yang Yan, Li Shu, Wang Yanyi, Li Ying, Diao Feici, Lei Caoqi, He Xiao, Zhang Lu, Tien Po, Shu Hongbing*, The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity, 2008, 29(4):538-550.