学习经历

2014-2018  浙江大学医学院，生物化学与分子生物学，博士

主要工作经历与任职情况

2019-2023  加州大学圣迭戈分校医学院，代谢与内分泌系，博士后。合作导师：Jerrold Olefsky，Wei Ying和Alan Saltiel教授

2023-至今    任武汉大学生命科学学院/泰康生命医学中心/细胞稳态湖北省重点实验室PI

主持课题项目

武汉大学海外人才引进科研启动经费

武汉大学泰康生命医学中心启动经费

国家自然科学基金青年项目

研究方向与成果

机体多脏器的联动很大程度上依赖于细胞间的通讯，而这些通讯无时无刻不在通过各种方式进行着。因此，破译细胞间的通讯语言是了解细胞完整功能的重要一环。这一问题既重要，也非常有趣。我们将从代谢性疾病入手，主要以肝脏，脂肪、胰岛及其相关免疫细胞为研究对象，以外泌体和微量元素为手段，结合多组学大数据分析，探索细胞是如何在代谢性疾病的发生发展过程中扮演worker（自身功能维持）和manager（通信物质释放与接收）的角色的。对于这一问题的回答，将有助于从整体上理解代谢性疾病的病理机制，也将为寻求治疗靶点提供新的思路和评价体系。课题组以第一或通讯作者（含共同）身份，发表学术论文10篇，其中包含3篇Cell Metabolism（2021,2022a,2022b）, Nature Communications(2022)及PNAS(2017)等国际著名杂志，并被多位知名科学家在Cell Metabolism, Nature Review Endocrinology, Faculty Opinions上重点推荐。

代表性论文（^#并列第一作者，^*通讯作者）

1. Hong Gao*, Zhongmou Jin, Gautam Bandyopadhyay, Gaowei Wang, Dinghong Zhang, Karina Cunha e Rocha, Xiao Liu, Huayi Zhao, Tatiana Kisseleva, David A. Brenner, Michael Karin*, Wei Ying* (2022) Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metabolism.

2. Hong Gao, Zhongmou Jin, Gautam Bandyopadhyay, Karina Cunha e Rocha, Xiao Liu, Huayi Zhao, Dinghong Zhang, Hani Jouihan, Soheil Pourshahian, Tatiana Kisseleva, David A. Brenner, Wei Ying*, Jerrrold M. Olefsky* (2022) MiR-690 Treatment Causes Decreased Fibrosis, Steatosis and Restores Kupffer Cell Function in NASH. Cell Metabolism.

3. Wei Ying#*, Hong Gao#, Felipe Castellani Gomes Dos Reis, Gautam Bandyopadhyay, Jachelle M. Ofrecio, Zhenlong Luo, Yudong Ji, Zhongmou Jin, Crystal Ly, Jerrold M. Olefsky* (2021) M2-polarized macrophage-derived exosomal miRNAs can improve insulin sensitivity in obesity. Cell Metabolism, DOI: 10.1016/j.cmet.2020.12.019

4. Hong Gao, Zhenlong Luo, Yudong Ji, Zhongmou Jin, Crystal Ly, Wei Ying*. (2022) A CRIg+ macrophage-dependent defense against gut microbial DNA containing extracellular vesicles-induced islet inflammation. Nature Communications, DOI: 10.1038/s41467-022-28239-2

5. Hong Gao#, Lu Zhao#, Hao Wang, Enjun Xie, Xinhui Wang, Qian Wu, Yingying Yu, Xuyan He, Hongbin Ji, Lothar Rink, Junxia Min* and Fudi Wang* (2017) The metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. Proceedings of the National Academy of Sciences USA. doi:10.1073/pnas.1708018114

6. Hong Gao#, Zhongmou Jin#, Kechun Tang#, Yudong Ji, Jorge Suarez, Jorge A. Suarez, Karina Cunha e Rocha, Dinghong Zhang, Wolfgang H. Dillmann, Sushil K. Mahata* and Wei Ying* (2021) Microbial DNA enrichment promotes adrenomedullary inflammation, catecholamine secretion, and hypertension in obese mice. Journal of the American Heart Association. DOI: 10.1161/JAHA.121.024561

7. Hong Gao, Zhenlong Luo, Zhongmou Jin, Yudong Ji, Wei Ying* (2021) Adipose tissue macrophages modulate obesity-Associated β cell adaptations through secreted miRNA-containing extracellular vesicles. Cells. doi: 10.3390/cells10092451

8. Hong Gao#, Wei Dai#, Lu Zhao*, Junxia Min*, Fudi Wang* (2018) The Role of Zinc and zinc homeostasis in Macrophage function. Journal of Immunology Research.

9. Xinhui Wang#, Hong Gao#, Wenhui Wu, Enjun Xie, Yingying Yu, Xuyan He, Jin Li, Wanru Zheng, Xudong Wang, Xizhi Cao, Zhuoxian Meng, Ligong Chen, Junxia Min, Fudi Wang (2018) The Zinc Transporter Slc39a5 Controls Glucose Sensing and Insulin Secretion in Pancreatic Β-Cells Via Sirt1- and Pgc-1α-Mediated Regulation of Glut2. Protein&Cell. https://doi.org/10.1007/s13238-018-0580-1

10. Yongjuan Xin#, Hong Gao#, Jia Wang#, Yuzhen Qiang, Mustapha Umar Imam, Yang Li, Jianyao Wang, Ruochen Zhang, Huizhen Zhang, Yingying Yu, Hao Wang, Haiyang Luo, Changhe Shi, Yuming Xu, Shintaro Hojyo, Toshiyuki Fukada, Junxia Min, Fudi Wang (2017) Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice. Cell Discovery, doi:10.1038/celldisc.2017.25