学习经历

2005-2010  中国科学院水生生物研究所 博士

2001-2005  武汉大学生命科学学院 学士

2010-2013  美国匹兹堡大学 博士后

主要工作经历与任职情况

2010-2013  美国匹兹堡大学 博士后

2014-至今   武汉大学生命科学学院

主要科研奖励和个人荣誉

2010年中国生命科学十大进展

研究内容

胆固醇是哺乳动物细胞中含量最丰富的甾醇类分子，为动物细胞生存所必需，具有重要的生理功能。首先胆固醇是动物细胞细胞膜的重要组成成分，占质膜脂类的20%以上，其作为细胞和环境之间的屏障可以调节细胞膜的流动性、通透性和相变。其次胆固醇是体内所有的类固醇激素和胆酸合成的前体物质，参与体内的正常代谢。最后胆固醇在神经系统的发育中也起着重要的作用。胆固醇的代谢紊乱会导致一系列严重的疾病，例如心血管疾病、动脉粥样硬化和胆结石等。有证据表明，肥胖症、糖尿病以及阿尔海默氏病 (Alzheimer’s Disease，老年痴呆症) 也与胆固醇代谢的紊乱有关。我们的研究兴趣是胆固醇代谢平衡

调控与代谢性疾病发生机理。

主要研究方向包括：1）小肠胆固醇吸收的分子途径；2）细胞内胆固醇动态运输的分子机制；3）胆固醇代谢调控的信号转导途径和机理；4）胆固醇代谢的药靶系统及新药研发。

主持课题项目

1. 国家重点研发计划，主要环境污染物对个体发育和代谢的影响及关键机制研究课题二：环境污染物干扰糖脂代谢的时空效应和分子机制研究，2022-12-1至2027-12-1

2. 面上项目 , 胆固醇合成影响卡路里限制时血糖稳定的机制研究，2023-01-01至2026-12-31

3. 重大研究计划，进食上调胆固醇合成的分子机制研究，2020-01-01至2022-12-31

4. 重大研究计划，细胞器膜接触介导胆固醇转运的分子机制与功能研究，2018-01-01至2020-12-31

5. 青年科学基金项目， lncRNA编码的小肽在胆固醇代谢调控中的功能，2018-01-01至2020-12-31

   
   

发表的论文（^#并列第一作者，^*通讯作者）

1. Zhi‐Ping Qiu, Zi‐Cun Lin, Ao Hu, Yuan‐Bin Liu, Wan‐Er Zeng, Xiaolu Zhao, Xiong‐Jie Shi, Jie Luo, Bao‐Liang Song. GRAMD1/ASTER‐mediated cholesterol transport promotes Smoothened cholesterylation at the endoplasmic reticulum. The EMBO Journal. 2023.

2. Ju-Qiong Wang, Liang-Liang Li, Ao Hu, Gang Deng, Jian Wei, Yun-Feng Li, Yuan-Bin Liu, Xiao-Yi Lu, Zhi-Ping Qiu, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature. 2022.

3. Biran Zhu, Lei Lei, Yumiao Sun, Xiongjie Shi, Kaiyu Fu, Jianghuan Hua, Christopher J Martyniuk, Jian Han, Lihua Yang, Bingsheng Zhou. Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish. Environmental Science & Technology. 2022.

4. Jin-Kai Wang, Yang Li, Xiao-Lu Zhao, Yuan-Bin Liu, Jing Tan, Yu-Ying Xing, Dilare Adi, Yong-Tao Wang, Zhen-Yan Fu, Yi-Tong Ma, Song-Mei Liu, Yong Liu, Yan Wang, Xiong-Jie Shi, Xiao-Yi Lu, Bao-Liang Song, Jie Luo. Ablation of plasma prekallikrein decreases low-density lipoprotein cholesterol by stabilizing low-density lipoprotein receptor and protects against atherosclerosis. Circulation. 2022.

5. Yuxi Zhou, Wei Guo, Lei Lei, Yumiao Sun, Ruiwen Li, Yongyong Guo, Lihua Yang, Xiongjie Shi, Jian Han, Bingsheng Zhou. Bis (2-ethylhexyl)-tetrabromophthalate induces zebrafish obesity by altering the brain-gut axis and intestinal microbial composition. Environmental Pollution. 2021.

6. Wei Guo, Lei Lei, Xiongjie Shi, Ruiwen Li, Qiangwei Wang, Jian Han, Lihua Yang, Lianguo Chen, Bingsheng Zhou. Wei Guo, Lei Lei, Xiongjie Shi, Ruiwen Li, Qiangwei Wang, Jian Han, Lihua Yang, Lianguo Chen, Bingsheng Zhou. Environmental Science & Technology. 2021.

7. Xuping Yang, Qinhui Liu, Yanping Li, Yi Ding, Yan Zhao, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Shihai Cheng, Jinhang Zhang, Zijing Zhang, Ya Huang, Rui Li, Yingnan Zhao, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He. Inhibition of the sodium–glucose co‐transporter SGLT2 by canagliflozin ameliorates diet‐induced obesity by increasing intra‐adipose sympathetic innervation. British Journal of Pharmacology. 2021.

8. Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein & cell. 2021.

9. Xiao-Yi Lu^#, Xiong-Jie Shi^#, Ao Hu^#, Ju-Qiong Wang^#, Yi Ding, Wei Jiang, Ming Sun, Xiaolu Zhao, Jie Luo, Wei Qi, Bao-Liang Song. Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis. Nature. 2020.

10. Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song. Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2. Nature Communications. 2020.